Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos

Summary: To interrogate the alternative fates of pancreas and liver in the earliest stages of human organogenesis, we developed laser capture, RNA amplification, and computational analysis of deep sequencing.Pancreas-enriched gene expression was less conserved between human LIP SHIMMER PLUM and mouse than for liver.The dorsal pancreatic bud was enr

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Physiologic Response Evaluation of Human Foetal Osteoblast Cells within Engineered 3D-Printed Polylactic Acid Scaffolds

Large bone defect treatments have always been one of the important challenges in clinical practice and created a huge demand for more efficacious regenerative approaches.The bone tissue engineering (BTE) approach offered a new alternative to conventional bone grafts, addressing all clinical needs.Over the past years, BTE research is focused on the

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